-
- Heasman PA, Heasman L, Stacey F, McCracken GI.
Restorative Dentistry, Dental School, University of Newcastle upon
Tyne, UK. p.a.heasman@newcastle.ac.uk
AIM: The aim of this randomised, split-mouth, single-blind study was
to determine the efficacy of controlled-release delivery of
chlorhexidine gluconate 2.5 mg (PerioChip) in patients with residual
bleeding pockets (>5 mm) at least 3 months following oral hygiene
and root debridement phase therapy. MATERIAL AND METHODS: 26 patients
(non-smokers) were screened and potential study sites identified.
Clinical parameters recorded at baseline and all subsequent visits
were plaque index (PI), pocket probing depth (PPD), bleeding index
(BI) and clinical attachment level (CAL). All study sites were
debrided using ultrasonic instrumentation. PerioChips (PC) were placed
in the selected sites of two quadrants (left or right) whilst
identified sites in the remaining quadrants were left without
adjunctive antimicrobial treatment. Clinical measurements were made at
follow-up visits after 1, 3 and 6 months. Mean changes from baseline
in PPD, BI and CAL were calculated with the patient as the
experimental unit and comparability between the treatments was
determined using t-tests. RESULTS: At baseline there were no
significant differences between PC and control sites for mean PI, PD,
BI or CAL. The mean (SE) reductions in PPD for PC and control
treatments were: 0.47 (0.1), 0.46 (0.1); 0.76 (0.1), 0.55 (0.1); 0.78
(0.1), 0.45 (0.1) for months 1, 3 and 6 respectively. Only at month 6
did the difference between treatments approach statistical
significance (p=0.06). Mean (SE) reductions in CAL over the same
periods were: 0.17 (0.1), 0.04 (0.08); 0.38 (0.1), 0.21 (0.1); 0.43
(0.1), 0.15 (0.09) p=0.048. Mean (SE) reduction in BI between PC and
control treatments only reached statistical significance at 6 months:
1.08 (0.1), 0.59 (0.1) p=0.05. CONCLUSION: These data suggest that
PerioChip is beneficial for patients on maintenance therapy although
the benefit is not apparent until 6 months after placement.
|
 |