Clinical and microbiological effects of minocycline-loaded
microcapsules in adult periodontitis.
Yeom HR, Park YJ, Lee SJ, Rhyu IC, Chung CP, Nisengard RJ.
Department of Periodontology, College of Dentistry, Seoul National
University, Korea.
Clinical and microbiological effects of subgingival delivery of 10%
minocycline-loaded (MC), bioabsorbable microcapsules were examined in 15
adult periodontitis patients. Patients received oral hygiene instruction 2
weeks prior to the study. At baseline (day 0) all teeth received
supragingival scaling (SC); 2 quadrants received no further treatment and 1
quadrant received subgingival scaling and root planning (SRP). In the fourth
quadrant, the tooth with the deepest probing sites (at least 1 site > or
= 5 mm) was treated with minocycline microcapsules. The sites were evaluated
at baseline and weeks 1, 2, 4, and 6. Clinical indices included bleeding on
probing (BOP), probing depths (PD), and attachment loss (AL).
Microbiological evaluations included percent morphotypes by phase-contrast
microscopy; cultivable anaerobic, aerobic, and black-pigmented Bacteroides (BPB);
and percent Porphyromonas gingivalis, Prevotella intermedia, Eikenella
corrodens, and Actinomyces viscosus by indirect immunofluorescence. In the
SC + MC group, BOP, PD, and AL were significantly reduced from baseline for
weeks 1 to 6. BOP in the SC + MC group was significantly reduced compared to
the SRP group from weeks 2 to 6. In the SC + MC group the percent of
spirochetes and motile rods decreased and the percent of cocci increased
after 1 week. The increased cocci and decreased motile rods were
statistically greater at weeks 4 and 6 in the SC + MC group compared to the
SRP group. This study demonstrates that local subgingival delivery of 10%
minocycline-loaded microcapsules as an adjunct to scaling results in
reduction in the percent sites bleeding on probing greater than scaling and
root planning alone and induces a microbial response more favorable for
periodontal health than scaling and root planing.