Clinical and microbiological effects of
controlled-release locally delivered minocycline in periodontitis.
Jones AA, Kornman KS, Newbold DA, Manwell MA.
Department of Periodontics, University of Texas Health Science Center at San
Antonio.
The clinical efficacy of minocycline in a subgingival local delivery system
was evaluated alone (M) or as an adjunct to scaling and root planing (M +
SRP), in comparison to scaling and root planing (SRP) or to no subgingival
treatment (NoTx) in adult periodontitis. Fifty-one adult patients with >
or = 7 mm periodontal pockets demonstrating the presence by culture of
Porphyromonas gingivalis (Pg), Prevotella intermedia (P(i)), or
Actinobacillus actinomycetemcomitans (Aa) were randomized into one of the
above 4 treatment groups. All sites > or = 5 mm in the most diseased
quadrant in each patient received the therapy. Other quadrants were not
treated. All patients received standardized oral hygiene instructions at the
beginning of the study. At 0, 1, 3 and 6 months following therapy the 7 mm
experimental sites were evaluated for selected periodontal pathogens by DNA
probe analysis. At these same time points, the plaque index, gingival index,
and bleeding on probing were evaluated as well as probing depth and relative
clinical attachment level which were assessed by means of an automated
probe. Probing depth reduction with M + SRP was significantly greater than
all other groups at one month and significantly greater than NoTx and SRP at
3 months. There were no differences in probing depth reduction among groups
at 6 months. At 6 months the gain in clinical attachment level was
significantly greater for SRP than for either the NoTx or M groups. The
prevalence of Pg decreased significantly in the M and M + SRP groups at one
month.(ABSTRACT TRUNCATED AT 250 WORDS)